CASP3 and Classical progressive supranuclear palsy: One prominent post translational modification that incites further tau deposition and neuropathology includes cleavage by caspase-3 at aspartate 421 (tau ΔD421) which associates with Pick’s disease (PiD) [15], corticobasal degeneration (CBD) [60], progressive supranuclear palsy (PSP) [14], and AD [9–12].