As a first step to better understand the similarities and differences in the inhibition of selected MLL-fusion-associated therapeutic targets, we tested all selected inhibitors (Table 1) in cell proliferation assays in two MLL-fused (MV4-11, MOLM-13) and one non-fused AML (HL-60) cell line (Fig. 1a). This evidence concerns the gene KMT2A and acute myeloid leukemia.