Among the negatively associated genes, BCL2 expression related to the anti-leukemia-associated genes such as CDKN2B, LGALS3, CDH6, THBS1, ITGB2, ROBO1, DOK2, DKK2, DKK1, and LEP. Furthermore, the Gene Ontology analysis revealed that these genes involved in biologic processes, including system development, signaling, cell communication, and cell adhesion (Fig. 4c). The gene discussed is DKK2; the disease is leukemia.