Several genes such as PAX2, HOXC6, HOXC10, HOXC9, SOX11, HOXD13, HOXC8, WT1, SALL4, HOXC11, HOXC4, HOXC12, HOXC5, and HOXD12 reported with proto-leukemia effects were identified within this signature positively correlated with BCL2 expression. The gene discussed is HOXC8; the disease is leukemia.