In addition, suppressive immune features indicating a poor prognosis of SCLC include the frequency of CD14+HLA-DR-/low myeloid-derived suppressor cells (MDSCs) [45], the C-reactive protein/albumin (CRP/Alb) ratio[46] and a higher Treg cell ratio in tumor infiltrates [47]. The gene discussed is CRP; the disease is small cell lung carcinoma.