Additionally, correlations between excision and upgrade rates to relevant clinicopathologic variables including personal history of remote breast cancer, mammographic target, needle size and use of vacuum assistance, use of confirmatory immunostains (CK5 or CK5/6), presence of background lesions such intraductal papilloma or lobular neoplasia, pathologist and surgeon, were evaluated for each diagnostic category. This evidence concerns the gene KRT5 and breast carcinoma.