The ER22/23EK polymorphism of GR gene has been associated with partial form of GC resistance [39] while BclI and N363S polymorphisms have been linked with higher GC sensitivity [40, 41].GR polymorphisms in BclI and N363S as well in 1β-HSD1 may increase individual predisposition to mood disorder including depression [42, 43]. This evidence concerns the gene NR3C1 and depressive disorder.