NR5A2 and breast cancer: Another study showed that down-regulation of miR-27b could confer tamoxifen resistance through up-regulation of NR5A2 and CREB1 expression in breast cancer cell lines (MCF7 and T47D), while upregulation of miR-27b expression enhanced the sensitivity of breast cancer cells to tamoxifen, suggesting a role for miR-27b in hormone therapy for breast cancer patients [35].