Suppression of tumorigenicity 14 (ST14), also known as matriptase, is an epithelial cell-specific membrane-anchored serine protease found to reduce cell proliferation and invasion of cancer cells [23], and adenomatous polyposis coli (APC), a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway [44], are both validated miR-27b targets. This evidence concerns the gene APC and cancer.