All the SNPs are laying in EGF-1 (Gln96Pro, Gly105Asp, Glu124Lys) and EGF-2 (Gln143Arg, Val153Met) domains, from which only Gly105Asp, that lies in EGF-1 near the interface with EGF-2, does not engage in any interactions with it, so it would explain that this mutation is associated to a Hemophilia B mild phenotype. This evidence concerns the gene GFM1 and hemophilia B.