On exploring the TCGA dataset, it was observed that all three Akt kinase isoforms have a considerable percentage of genetic alterations in HNSCC, but in our study, the IHC analysis of oral cancer tissues showed high expression of Akt1 and 2 isoforms but not Akt3 compared to the normal tissues. Here, AKT3 is linked to head and neck squamous cell carcinoma.