Although more than 50 ALS-associated genes have been identified, including superoxide dismutase 1 (SOD-1), fused in sarcoma (FUS), and chromosome 9 open reading frame 72 (C9ORF72) [14,15], only a small proportion of sporadic ALS patients (accounting for more than 90% of all ALS cases) carry any mutations in these genes. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.