VEGFA was suggested to play a role in neuroprotection via activating VEGF receptor 2 and neuropilin-1 in various neurodegenerative diseases, including ALS [139] and mice with a homozygous deletion in the hypoxia response element of the VEGFA promoter exhibited classical ALS-like symptoms [140]. Here, NRP1 is linked to amyotrophic lateral sclerosis.