PIK3CA and nervous system disorder: Neurotrophic factors, including BDNF, neurotrophic receptor tyrosine kinase 2 (NTRK2), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), AKT serine/threonine kinase 1 (AKT1), glycogen synthase kinase 3β (GSK3β), nuclear factor κB (NFκB), and Fas ligand (FASLG), play roles in the development and synaptic plasticity of the nervous system, suggesting pathogenic roles in neurological diseases [144].