Studies in cervical cancer cells demonstrated that STIM1 regulates EGF-stimulated migration through the activation of several Ca2+-dependent molecules such as cytosolic tyrosine kinase Pyk2, calpain protease, and MLCK, as well as the recruitment of the active focal adhesion proteins, including Pyk2, FAK, and talin, and thereby facilitating focal adhesion turnovers, cytoskeleton reorganization, and actomyosin-mediated mechanotransduction [30,87]. The gene discussed is PTK2B; the disease is cervical carcinoma.