ORAI1 and graft versus host disease: Except for the small-molecule inhibitors of SOCE, a newly generated anti-Orai1 monoclonal antibody with specificity for the second extracellular loop was reported to cause cellular internalization of Orai1 and resulting in inhibiting in vitro T-cell activation and cytokine production and in vivo T-cell-mediated graft versus host disease in a mouse model [152].