Mechanistic studies in cervical cancer cells showed that inhibition of SOCE by pharmacological blockers or silencing of STIM1 or Orai1 reduced the phosphorylation of the cyclin-dependent kinase CDK2 and upregulated cyclin E expressions, resulting in the cell cycle arrest in G1/S transition accompanied with autophagy [31]. The gene discussed is CDK2; the disease is cervical cancer.