In breast cancer MDA-MB-231 cells, upregulation of Orai1 or STIM1 significantly increased the in vitro migratory capability and tumor metastasis potential in mice, whereas silencing of Orai1 or STIM1, as well as SOCE blockade with SKF-96365, attenuated these effects [82]. This evidence concerns the gene ORAI1 and neoplasm.