The canonical STIM1/Orai1-mediated SOCE mechanism has been found to be required for cell migration of several cancer types, including breast cancer [82], cervical cancer [30], gastric cancer [83], colorectal cancer [32,33], hepatocellular carcinoma [34], renal cell carcinoma [36], nasopharyngeal carcinoma [84], glioma [85], and melanoma [86]. The gene discussed is STIM1; the disease is cancer.