For instance, STIM1 or Orai1 is overexpressed in tumor tissues when compared with noncancerous or precancerous tissues in patients with breast [29], cervical [24,27,30,31], colorectal [32,33], liver [34], lung [35], clear cell renal cancers [36], or multiple myeloma [37]. Here, ORAI1 is linked to plasma cell myeloma.