In breast cancer MDA-MB-231 cells, upregulation of Orai1 or STIM1 significantly increased the in vitro migratory capability and tumor metastasis potential in mice, whereas silencing of Orai1 or STIM1, as well as SOCE blockade with SKF-96365, attenuated these effects [82]. The gene discussed is STIM1; the disease is breast cancer.