In the study of An et al. using mouse with DNCB-induced AD, topical application of melittin significantly alleviated AD-like symptoms, such as dorsal skin thickness by decreasing the number of mast cell infiltration, CD4+ T cells and the serum level of IgE, IL-4, IFN-γ, and TSLP. This evidence concerns the gene IGHE and Alzheimer disease.