STAT3 and cancer: The molecular mechanisms underlying the anticancer or antimetastatic activities of apigenin are thought to involve the targeting of mitogen-activated protein kinase (MAPK)/nuclear factor kappa B, phosphorylated Janus kinase 1 (pJAK1)/STAT3 signaling, vascular endothelial growth factor (VEGF), and aromatase in cancer cells [27,31,32].