The expression levels of snail, vimentin, and N-cadherin proteins, representative biomarkers of EMT process, were also significantly inhibited in the tumors derived from IL-6 shRNA-treated MDA-MB-231 cells (Figure 5c), indicating that IL-6 expression is directly associated with tumor metastasis through the regulation of snail, vimentin, and N-cadherin expression. This evidence concerns the gene CDH2 and neoplasm.