For example, in AD patients and animal AD models some genes are hypermethylated (MTHFR, APOEε4, MAPT, SORBS3, Tau), while others are hypomethylated (CREB5, S100A2, PP2A, BACE, PS1) or exhibit no significant difference (APP) [35,129]. The gene discussed is SORBS3; the disease is Alzheimer disease.