The aim of this study was to determine whether a dietary intervention based on the introduction of two different types of calorie restriction induce significant changes in body mass and body composition, as well as metabolic indicators, such as insulin resistance (HOMA-IR), concentration of leptin, adiponectin, IGF-1, glucose, total cholesterol, triglycerides, and HDL and LDL cholesterol. The gene discussed is LEP; the disease is Insulin resistance.