However, most prospective interventional studies in children with obesity have failed to demonstrate a beneficial effect of vitamin D administration on fasting lipids, glucose, insulin and CRP values [47,48,50,51], and insulin secretion or sensitivity [52], and dose response studies have similarly not been able to demonstrate an effect of increasing vitamin D doses on fasting glucose, insulin and insulin resistance [48,51] or lipid levels [48]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.