CD4 and flatulence: A significant increase in the proportion of both CD4+ and CD8+ T cells from the same TCR Vβ subset, which is more likely to be indicative of strong perturbation of TCR Vβ family members, was detected in only three individuals: An RT patient with GAS (emm28) and skewing of TCR Vβ2; another RT patient with skewing of TCR Vβ12; and a tonsillar hyperplasia patient with S. aureus and skewing of TCR Vβ13.2 (Supplemental materials, Table S1).