Results reported by Xie et al. reveal that non O blood groups has a lower likelihood of developing SCC and BCC than the O blood group; their study included Caucasians, however, without data on their origin, which is important information considering the ethnic heterogeneity of the USA population and the fact that the frequency of human genes of the ABO system varies among different populations and ethnic groups [10,33]. This evidence concerns the gene ABO and skin basal cell carcinoma.