Dysregulation of negative feedback for TLR4 signaling may exacerbate inflammation, inducing inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), both of which are associated with downregulation of tumor necrosis factor-α-induced protein 3 (TNFAIP3) and suppressor of cytokine signaling (SOCS) [15,16,17]. This evidence concerns the gene CISH and rheumatoid arthritis.