For example, miR-21-5p, a negative regulator of TLR4 via targeting of the proinflammatory tumor suppressor programmed cell death 4 (PDCD4), is thought to be important following an experimental model of autoimmune encephalomyelitis [19], and miR-146 and miR-125, which are involved in the regulation of innate immunity and inflammation, are associated with RA [20]. The gene discussed is TLR4; the disease is rheumatoid arthritis.