Mining the DGI GWAS for genes involved in OXPHOS led to the identification of a common variant (rs950994) located in intron 2 of the human TFB1M gene, and subsequently analysis of a prospective cohort revealed a pathogenetic effect of the risk variant in individuals carrying an A-allele, which could predict the occurrence of T2D in future. Here, TFB1M is linked to type 2 diabetes mellitus.