IGF2 and Beckwith-Wiedemann syndrome: In humans, pediatric undergrowth and overgrowth disorders, such as Silver-Russell and Beckwith-Wiedemann syndromes, respectively, are associated with corresponding alterations in levels of IGF2 [7, 8], and changes in IGF2/Igf2 gene expression influence tissue and organismal growth in pigs and mice [9–12].