Indeed, as illustrated by immunoblot on the derived colonic epithelial lysates, wild-type CR infection caused striking decreases in the protein levels of occlusive claudins (e. g. claudin-3, -4, -6, -11, and -19) and pore-forming claudins (e. g. claudin-2 and -15), as well as some TJ-associated proteins and EspF-interacting proteins including ZO-1, 14-3-3σ, profilin, and arp2 in the infected Il22-/- mice (Figs 3G and 3H and S4). Here, IL22 is linked to infection.