Consistently, infection with wild-type CR caused substantial weight loss, elevated clinical score, and severe lethality with 100% death in Il22-/- mice within 14 dpi (Fig 2D–2F); whereas ΔespF CR infection resulted in substantially less weight loss, attenuated diarrhea severity and mortality in the infected animals (Fig 2D–2F), as did the Mut-19 CR strain (Fig 1A–1D). Here, IL22 is linked to infection.