Indeed, at 3 h post infection, the protein levels of claudin-3, one of the most abundant TJ transmembrane proteins [43,44], were profoundly decreased in CMT-93 cells infected with wild-type CR, in comparison to PBS control (S3 Fig), indicating impaired claudin-3 dynamics or possible degradation, as previously shown in other types of cells [41]. Here, CLDN3 is linked to infection.