Several studies revealed that, exposure to hypobaric hypoxia (HH) results into an up surge in the levels of nuclear factor kappa B (NF-κB) and increased expression of hypoxia inducible factor (Hif-1α), leading to the activation of numerous genes involved in the progression of oxidative stress, inflammation, angiogenesis, erythropoesis, apoptosis etc. [9,10].This cumulative effect would result into increased inflammation, elevated vascular leakage and ends up with the development of pulmonary edema [11,12]. Here, NFKB1 is linked to pulmonary edema.