Therefore, it can be interpreted that quercetin prophylaxis at molecular level attenuates hypoxia induced transvascular leakage by down regulating the inflammation, alveolar oxidative stress, extravasation of plasma proteins into the lung interstitium, promoting the production of anti-inflammatory cytokines and stabilizing the expressions of HIF-1α followed by reduced VEGF expressions resulting into the prevention of hypoxia induced pulmonary edema. The gene discussed is VEGFA; the disease is pulmonary edema.