TRIM56 and Zika virus infectious disease: As shown in Fig 9D, these cells were found to have basal expression of Trim56. In line with the expression pattern of TRIM56 transcript in SVGA cells, Trim56 mRNA abundance was upregulated by ~ 2-fold at 48 h.p.i. In aggregate, the experiments show that TRIM56 is expressed in human and mouse neural cell types, which moderately upregulate the expression of this antiviral protein in response to ZIKV infection.