MFAP4 has recently been shown to promote the development of asthma in vivo and display proasthmatic properties of bronchial smooth muscle cells in vitro and has been suggested to contribute to allergic asthma by promoting airway eosinophilia, airway hyperresponsiveness, and lung remodeling through regulation of ASM proliferation and eotaxin secretion in experimental studies.11 The gene discussed is MFAP4; the disease is asthma.