PKD1 and colonic neoplasm: Cancer and PKD are frequently accompanied by aberrant activation of the mTOR pathway.29, 30, 31, 32, 33, 34 Previous data have demonstrated that PC1 overexpression in SW480 colon cancer cells leads to down‐regulation of mTOR signalling.43 Jak signalling also becomes up‐regulated in cancer35, 36, 37 and studies have shown that PC1 activates Jak signalling in PKD.38, 39, 40, 41, 42 Therefore, we investigated if the mTOR and Jak pathways are affected by changes in the function of PC1 in cancer cells.