IgPKD1 has been used to block PC1 in murine, canine and human kidney epithelial cells,16, 17, 44 bone cells,45, 46 CRC cells and xenografts43 and endothelial cells.47 We found that in A549 cells, IgPKD1 treatment led to increased cell migration with the greatest effect observed at a 1:50 dilution of the IgPKD1 antibody (Figure 2C). This evidence concerns the gene PKD1 and colorectal carcinoma.