Analysing colorectal cancer (CRC) cell lines (HCT116, HT29 and SW480), HT29 tumour xenografts and cancer tissue samples from CRC patients, Gargalionis et al provided evidence of a role for polycystins in CRC aggressiveness.43 In the present study, our goal was to examine the in vitro role of PC1 in cancer using cancer cell lines derived from five different types of human cancer (brain—GOS3, lung—A549, prostate—PC3, colon—HT29, breast—MCF7). Here, PKD1 is linked to colorectal carcinoma.