In addition, given that PC1 and PC2 physically interact via their cytoplasmic C‐terminal tails, it is possible that they modulate each other's subcellular localization, but this remains controversial.51 Similarly to renal epithelial cells, all cell lines used in our study, apart from glioblastoma cells (GOS3), are epithelial in origin. This evidence concerns the gene PKD1 and glioblastoma.