Indeed, mouse models of inherited retinal degeneration are unresponsive to hypoxia and lack of angiogenic profiles likely due to their low levels of both HIF‐1 and vascular endothelial growth factor (VEGF)38, 39 thus rendering them suitable to answer the question whether HIF‐1 regulates retinal expression of UPA/UPAR in hypoxic environment. The gene discussed is PLAUR; the disease is retinal degeneration.