Among the most common types of albinism, only the OCA1 subtype is actually caused by mutations in the tyrosinase gene.53 In turn, within OCA1 subjects, tyrosinase activity is completely abolished only in the OCA1A subtype while in OCA1B some enzymatic activity still remains, allowing some accumulation of melanin pigment over time.53 In this context, at least one of the subjects examined by Foley and Baxter was diagnosed with “partial albinism,”51 implying that some residual tyrosinase activity could have been present in these brains. This evidence concerns the gene TYR and piebaldism.