CD4 and type 2 diabetes mellitus: In people living with T2D we found a significant reduction in the naïve pool in both CD4+ and CD8+ populations; this was accompanied by a significant rise in the more differentiated EM and senescent EMRA populations of the CD4+ subset and CM and EMRA populations of the CD8+ T cells compartment compared to age‐matched controls (Fig. 1c,d).