In dominant model, it was found that KQ/QQ genotypes of PC‐1 K121Q polymorphism contributed to only 19.2% occurrence of insulin resistance (OR = 0.22, 95% CI = 0.10–0.49, p < 0.001 and after adjustment OR = 0.07 95% CI = 0.00–2.36, p = 0.055). This evidence concerns the gene ENPP1 and Insulin resistance.