Drug response of MCF‐7 morphology, adhesion, and cell‐to‐cell interaction were visualized with surface membrane proteins, such as the membrane‐bound mucin marker MUC‐1 overexpressed in breast carcinoma 39, cell adhesion molecule EpCAM, integrin CD29, tetraspanin CD81, the low‐expressed epidermal growth factor receptor EGFR, regulators of integrin‐mediated cell adhesion CD98 and CD47 40, and E‐cadherin as epithelial interaction protein (Table S2). This evidence concerns the gene CD81 and breast carcinoma.