JQ1 is a novel small molecule that selectively targets and inhibits BET bromodomain, thereby suppressing the tumor through c‐Myc‐dependent and c‐Myc‐independent mechanisms.8, 9 Recent studies demonstrate that JQ1 inhibits BC cell proliferation via triggering apoptosis and inducing cell cycle arrest both in vitro and in vivo, which confirmed its anticancer potential toward BC.10 However, the underlying mechanism is not fully understood yet. This evidence concerns the gene DNER and breast cancer.