Recently, it has been proposed that SAA could be a mechanistic link between obesity and cardiovascular disease, by virtue of promoting inflammation at the level of the adipose tissue, leading to insulin resistance 42, 43 and dyslipidemia 42, and that it can improve with weight loss 44 and statin therapy 42, 45. This evidence concerns the gene SAA1 and obesity due to melanocortin 4 receptor deficiency.