Two potential binding sites between MALAT1 and miR‐203 were identified based on starBase as shown in Figure 4A. Dual‐luciferase reporter gene assay indicated that the luciferase activity of the group co‐transfected with miR‐203 mimics and MALAT1‐wt was lower than that of the group co‐transfected with miR‐203 NC and MALAT1‐wt (Figure 4B, **P < 0.01), while MALAT1‐mut did not affect luciferase activity, suggesting a targeted relationship between miR‐203 and MALAT1 in RCC. This evidence concerns the gene MALAT1 and renal cell carcinoma.