The CCK‐8, flow cytometry, transwell and wound healing assays indicated that the overexpression of BIRC5 greatly accelerated cell proliferation (Figure S1C‐D), decreased the percentage of RCC cells in G0/G1 phase (Figure S1E‐H, *P < 0.05) and promoted cell invasion (Figure S2A‐D, **P < 0.01, ##P < 0.01) and cell migration (Figure S2E‐H, **P < 0.01, ##P < 0.01) in both A498 and OS‐RC‐2 cells, respectively. Here, BIRC5 is linked to renal cell carcinoma.