RCC patients with high MALAT1 expression had more advanced clinical features and a shorter overall survival time than those with low MALAT1 expression.36 MALAT1 promoted cancer cell proliferation and metastasis through activating the ERK/MAPK pathway and interacting with hnRNP during cell cycle regulation.19 In the same way, our study explored the mechanism of action between them. This evidence concerns the gene MALAT1 and renal cell carcinoma.