The expression levels of Id-1 and CCN2 were investigated in seven HCC cell lines with different malignancy phenotypes of oxaliplatin resistance (IC50: HCC-M3, 32.10 ± 3.28; HCC-97H, 28.98 ± 2.37; PLC, 7.10 ± 1.49; Hep3B, 4.52 ± 0.88; HepG2, 7.01 ± 0.75; Huh7, 3.86 ± 0.58; L02, 5.78 ± 0.32). Here, CCN2 is linked to hepatocellular carcinoma.