CCN2 and hepatocellular carcinoma: Both the Id-1 and CCN2 levels were significantly increased in HCC cell lines with high metastatic potentials and strong resistance to oxaliplatin (HCC-LM3 and HCC-97H), whereas relatively lower CCN2 and Id-1 levels were detected in HCC cell lines with low metastatic potential and weak oxaliplatin resistance (PLC, HepG2, Huh7, and Hep3B) and in the human liver cell line (L-02; Fig. 1c).