In the case of construction of oxaliplatin-resistant HCC cell lines, firstly, we treated the oxaliplatin-resistant MHCC-97H cells with different concentrations of oxaliplatin, and found that the expression levels of CCN2, Id-1, LRP6, p-Erk, and E-cadherin varied in a dose-dependent manner (Supplementary Fig. 10A). This evidence concerns the gene LRP6 and hepatocellular carcinoma.