KDR and neoplasm: The findings of our study suggest an algorithm to facilitate early PCF diagnosis and hence a prompt surgical intervention: Preoperatively, high risk patients should be identified by screening for existing risk factors as well as for the expression of a B1-R membrane-bound score ≥ 5 or a VEGF-R2 endothelial expression ≥ 5 vessels/fov in the tumor samples.