TLR2 is able to recognize components of gram-positive bacteria and to exert effects on platelet signal transduction, aggregation, adhesion, or on platelet–neutrophil interactions.7, 8, 9, 10, 11The synthetic ligand Pam3Cys-Ser-(Lys)4 (Pam3CSK4), a triacylated peptide, has frequently been used for platelet TLR2 stimulation in experimental studies.7, 8Lipopolysaccharide (LPS) is an outer membrane component of gram-negative bacteria and a potent mediator of bacterial sepsis. This evidence concerns the gene TLR2 and bacterial infectious disease with sepsis.