ESAM and deep vein thrombosis: Based on the zebrafish data, both ESAM and DCBLD2 were proposed to be negative regulators of thrombus formation, which indeed was already published in the same year for ESAM in mice.49However, in mice, only modest effects of full DCBLD2 KO could be observed in vitro and in the in vivo FeCl3mesenteric artery thrombosis model.