However, vitamin K antagonists are the treatment of choice for antiphospholipid syndrome, protein S or protein C deficiency, while DOAC's use is still controversial.38, 39, 40, 41Additional studies designed to evaluate the efficiency of DOAC-Stop® treatment with a larger range of DOAC's concentration on more coagulation tests (including clotting factors and instruments using optical clot detection) will also be useful. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.