The impact of DOACs on laboratory assays used for thrombophilia testing (e.g., antithrombin, protein S, protein C, lupus anticoagulant, and activated protein-C resistance [APC-R]) is a well-known issue and may cause false-positive and -negative results.5, 6, 7, 8, 9Therefore, the correct interpretation of results that are performed in patient taking DOACs is mandatory to prevent misclassification and the subsequent clinical consequences.7 The gene discussed is PROS1; the disease is poisoning.