Oppositely to in vivo study which demonstrated no impact of imatinib on total cholesterol and triglycerides levels in diabetic mice,29imatinib is associated in CML patients with a rapid and progressive decrease of cholesterol and triglycerides levels.66, 73, 74, 75First hypothesis relates the inhibition of PDGFR by imatinib (Fig. 3). The gene discussed is PDGFRB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.