RHOA and Venous thrombosis: Dasatinib also induces endothelium leakage in vitro, and the RhoA-ROCKqpathway is involved in this phenomenon.94It was demonstrated that RhoA activation induces the phosphorylation of myosin light chain that increases the actomyosin contractibility and disrupt endothelial barrier.94Therefore, increased endothelium permeability is a potential mechanism by which dasatinib and nilotinib promote atherosclerosis development and arterial thrombosis.