Additional hypotheses suggest that inhibition of Abl kinase (i.e., Argrand c-Abl) and PDGFR might also be implicated in vascular leakage.85Finally, Guignabert et al demonstrated that both in rats and in CML patients taking dasatinib, there is an increase of soluble adhesion molecules, which are well-known markers of endothelial dysfunction.87 The gene discussed is PDGFRB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.