Relevant articles published from the database inception to July 11, 2017, were identified from an electronic database (PubMed) using the keywords “vascular,” “thrombosis,” “atherosclerosis,” “arteriosclerosis,” “venous,” “arterial,” “hemostasis,” “metabolic,” “metabolism,” “glycemia,” “glycaemia,” “cholesterol,” “triglycerides,” and “platelet” combined with the five approved BCR-ABL TKIs. The gene discussed is ABL1; the disease is atherosclerosis.