High level expression of HS3ST3B in U937 leukemia cells was associated with activation of Notch-1, Erk1/2 and Akt signalling (30), and more recently, the tumor-promoting effects of HS3ST2, HS3ST3B, and HS3ST4 were related to sustained activation of Src, Akt, and NF-κB, and up-regulation of the anti-apoptotic proteins survivin and XIAP (25). Here, HS3ST4 is linked to neoplasm.