PVT1 and breast cancer: In clear cell renal cell carcinoma as well as breast cancer, PVT1 was found to competitively bind miRNAs from the miR-200 family.The miR-200 family has been shown to prevent tumorigenesis and malignancy (18, 26) miR-200 family expression significantly reduces epithelial-mesenchymal transition in mutant p53 expressing cells when exposed to a carcinogen (74).