A knockdown of PVT1 via short interfering RNA (siPVT1) resulted in decreased cell viability in prostate cancer, melanoma, glioblastoma, gastric cancer, clear cell renal cell carcinoma, breast cancer, and colorectal cancer cell lines (18, 27, 31, 32, 35, 45, 50, 64). This evidence concerns the gene PVT1 and clear cell renal carcinoma.