MMP2 and hepatocellular carcinoma: For instance, hsa-miR199a-3p was observed significantly lower in the tumor tissues compared with their adjacent non-tumor tissues in patients with HCC, and further research found that hsa-miR199a-3p can suppress tumor growth, migration, invasion, and angiogenesis via targeting VEGFA, VEGFR1, VEGFR2, HGF, and MMP2 proteins in HCC (20).