Some studies demonstrated an insulin-sensitizing role of Metrnl in genetically engineered mouse.11,15 Tested by different methods, insulin resistance induced by a High Fat Diets (HFD) was impaired in adipocyte-specific Metrnl knockout subjects; otherwise transgenic mice with an overexpressing Metrnl in adipocytes were protected from diet-induced insulin resistance. Here, INS is linked to Insulin resistance.