The overexpression of Metrnl in adipose tissue is also different from insulin resistance in mice with leptin deficiency.11 The present study provided evidence that testifies adipose Metrnl is likely to improve overall insulin resistance on local adipose tissues in both autocrine and paracrine fashion.11 These researchers explained their evidence as follows: Firstly, although the phenotypes regarding insulin resistance in mouse models were obvious and clear, their serum Metrnl concentrations did not change compare to the control group. Here, METRNL is linked to Insulin resistance.