As shown in Table 2, the higher COL6A3 level was significantly associated with increased lymph node metastasis (P = 0.0233), whereas the elevated expression of SERPINH1 was associated with advanced age (P = 0.0034) and poor differentiation (P = 0.0231) in GC patients. The gene discussed is SERPINH1; the disease is metastatic malignant neoplasm in the lymph nodes.