The senescence-accelerated OXYS rat is an animal model of AMD that can spontaneously undergo an AMD-like retinopathy, including RPE degeneration, loss of photoreceptors, and the decreased expression of vascular endothelial growth factor (VEGF) and pigment epithelial-derived factor (PEGF) [35, 36]. Here, VEGFA is linked to age-related macular degeneration.