Long-term and chronic oxidative stress, which are pathogenic factors of AMD, can be generated by cigarettes, hydrogen peroxide (H2O2), tert-butyl hydroperoxide (TBHP), and light and can result in the premature aging of RPE cells, which is characterized by increases in ROS and SA-β-GAL activities, higher expression levels of p53, p21WAF1/CIP1, p16INK4A, and SASP factors, the accumulation of p-γH2AX foci and 8-OHdG DNA damage lesions, mitochondrial dysfunction, increased VEGF, and decreased CFH [41–44]. The gene discussed is VEGFA; the disease is age-related macular degeneration.