Defective placentation results in a decrease in the angiogenic vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) and the release of deleterious placental factors like soluble fms-like tyrosine kinase 1 (sFIt1) into the maternal circulation causing generalized endothelial dysfunction [56, 57]. The gene discussed is VEGFA; the disease is endothelial dysfunction.