Improvement in blood glucose, insulin secretion and HOMA-IR has been reported in postmenopausal women with abdominal obesity [48], with insulin resistance [15] and or in healthy postmenopausal women [44], as well as in a group of adult men and women with Type 2 diabetes [49, 50], whereas this was not observed in some studies [26, 47]. This evidence concerns the gene INS and Abdominal obesity.