Given that some lncRNAs are involved in SCA7 and HD pathogenesis (Lin et al., 2014; Roberts et al., 2014; Tan et al., 2014; Zhang et al., 2016; Salta and De Strooper, 2017; Sunwoo et al., 2017; Gagliardi et al., 2018) and that we previously detected abnormal expression of three lncRNAs in the SCA3/MJD mouse model (Vidal et al., 2000), we speculated that some lncRNAs also contribute to SCA3/MJD pathogenesis. This evidence concerns the gene ATXN3 and Huntington disease.