DNMT1 and hepatocellular carcinoma: Complementary to these findings, Mudbhary et al. (2014) demonstrated in both zebrafish hepatocytes and hepatocellular carcinoma that UHRF1 overexpression promotes DNMT1 destabilization and de-localization, driving DNA hypomethylation; further, UHRF1 increased expression was already associated with poor prognosis in hepatocellular carcinoma, contributing to cell proliferation and metastasis (Liu et al., 2017).